Evaluation of the effects of ozone therapy on Escherichia coli-induced cytitis in rat.
Ir J Med Sci
; 182(4): 557-63, 2013 Dec.
Article
en En
| MEDLINE
| ID: mdl-23456133
OBJECTIVES: The aim of the study was to investigate the effect of ozone on oxidative/nitrosative stress and bladder injury caused by Escherichia coli in rat bladder. METHODS: Twenty-one Wistar-Albino-type female rats included in the study were divided into three groups of equal number: (1) sham operation (control), (2) E. coli-only (EC), (3) EC + ozone. After ozone therapy for 3 days, urine and tissue samples were obtained for biochemical, microbiological, and histopathological analysis. RESULTS: Tissue malondialdehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) level were increased, whereas superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity was decreased in the EC group. MDA, MPO, and NO levels were decreased, whereas SOD, GPx activity was increased in the ozone-treated group. Also, there was no bacterial translocation in this group. CONCLUSION: The results of the present study suggest that ozone may be used as an agent to protect the bladder from oxidative/nitrosative stress occurring in cystitis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ozono
/
Infecciones Urinarias
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Vejiga Urinaria
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Cistitis
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Infecciones por Escherichia coli
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Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
Ir J Med Sci
Año:
2013
Tipo del documento:
Article
Pais de publicación:
Irlanda