Cytotoxic and antimalarial amaryllidaceae alkaloids from the bulbs of Lycoris radiata.
Molecules
; 18(3): 2458-68, 2013 Feb 25.
Article
en En
| MEDLINE
| ID: mdl-23439562
Phytochemical investigation of the 80% ethanol extract of the bulbs of Lycoris radiata resulted in the isolation of five new Amaryllidaceae alkaloids: (+)-5,6-dehydrolycorine (1), (+)-3α,6ß-diacetyl-bulbispermine (2), (+)-3α-hydroxy-6ß-acetyl- bulbispermine (3), (+)-8,9-methylenedioxylhomolycorine-N-oxide (5), and 5,6-dihydro-5- methyl-2-hydroxyphenanthridine (7), together with two known compounds, (+)-3α-methoxy- 6ß-acetylbulbispermine (4) and (+)-homolycorine- N-oxide (6). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. Alkaloid 1 showed potent cytotoxicity against astrocytoma and glioma cell lines (CCF-STTG1, CHG-5, SHG-44, and U251), as well as HL-60, SMMC-7721, and W480 cell lines with IC(50) values of 9.4-11.6 µM. Additonally, compound 1 exhibited antimalarial activity with IC(50) values of 2.3 µM for D-6 strain and 1.9 µM for W-2 strain of Plasmodium falciparum.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Raíces de Plantas
/
Lycoris
/
Alcaloides de Amaryllidaceae
/
Antimaláricos
Límite:
Humans
Idioma:
En
Revista:
Molecules
Asunto de la revista:
BIOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Suiza