Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease.
Ann Neurol
; 73(4): 554-9, 2013 Apr.
Article
en En
| MEDLINE
| ID: mdl-23424051
Ceruloplasmin is an iron-export ferroxidase that is abundant in plasma and also expressed in glia. We found a â¼80% loss of ceruloplasmin ferroxidase activity in the substantia nigra of idiopathic Parkinson disease (PD) cases, which could contribute to the pro-oxidant iron accumulation that characterizes the pathology. Consistent with a role for ceruloplasmin in PD etiopathogenesis, ceruloplasmin knockout mice developed parkinsonism that was rescued by iron chelation. Additionally, peripheral infusion of ceruloplasmin attenuated neurodegeneration and nigral iron elevation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model for PD. These findings show, in principle, that intravenous ceruloplasmin may have therapeutic potential in PD.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Ceruloplasmina
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Aged
/
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Ann Neurol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Australia
Pais de publicación:
Estados Unidos