Association between eosinophilic airway inflammation and persistent airflow limitation.
J Asthma
; 50(4): 342-6, 2013 May.
Article
en En
| MEDLINE
| ID: mdl-23414249
OBJECTIVE: We aimed to evaluate the association between eosinophilic inflammation in induced sputum and pulmonary function and persistent airflow limitation in children. METHODS: A total of 92 asthmatic children and 72 controls were enrolled in this study. Eosinophil count (%) and eosinophil cationic protein (ECP) levels were measured in induced sputum. We performed spirometry and a methacholine challenge test, and measured total eosinophil count, total serum IgE, and serum ECP in all subjects. RESULTS: Asthmatic children had significantly higher levels of sputum eosinophils (9% vs. 0%; P < 0.001) and sputum ECP (2.3 ± 0.7 vs. 1.6 ± 0.6 log µg/L, p < .001) than controls. Sputum ECP levels showed a significant negative correlation with post-bronchodilator (post-BD) FEV(1) (r = -0.307; p = .001) and post-BD FEV(1)/FVC (r = -0.286; p = .002), whereas sputum eosinophils showed no correlation with post-BD FEV(1) and post-BD FEV(1)/FVC. However, no significant differences in sputum ECP and sputum eosinophil counts were observed in asthmatic children with and without persistent airflow limitation. CONCLUSIONS: Our findings suggest that sputum eosinophilic inflammation, especially ECP, is associated with pulmonary function and persistent airflow limitation, which is manifested by low post-BD FEV(1)/FVC.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Asma
/
Esputo
/
Eosinófilos
/
Inflamación
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Asthma
Año:
2013
Tipo del documento:
Article
Pais de publicación:
Reino Unido