Structure and evolutionary origins of the CMG complex.
Chromosoma
; 122(1-2): 47-53, 2013 Mar.
Article
en En
| MEDLINE
| ID: mdl-23412083
The CMG (Cdc45-MCM-GINS) complex is the eukaryotic replicative helicase, the enzyme that unwinds double-stranded DNA at replication forks. All three components of the CMG complex are essential for its function, but only in the case of MCM, the molecular motor that harnesses the energy of ATP hydrolysis to catalyse strand separation, is that function clear. Here, we review current knowledge of the three-dimensional structure of the CMG complex and its components and highlight recent advances in our understanding of its evolutionary origins.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN Helicasas
/
Proteínas de Ciclo Celular
/
Proteína 1 de Mantenimiento de Minicromosoma
/
Proteínas de Unión al ADN
/
Replicación del ADN
Límite:
Humans
Idioma:
En
Revista:
Chromosoma
Año:
2013
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Austria