Role of interaction of the tanycytes of the third ventricle of the brain with the vascular bed endothelium in enzymatic activation of the parkinsonism-inducing proneurotoxin MPTP in rat brain.
Folia Morphol (Praha)
; 38(1): 24-7, 1990.
Article
en En
| MEDLINE
| ID: mdl-2341077
The authors describe the localization of monoaminooxidases oxidizing the protoxin MPTP to the active neurotoxic MPP+ ion, which induces parkinsonism by destroying the dopaminergic neurons of the nigrostriatum. Apart from some types of magnocellular neurons of the hypothalamus, enzymatic activity is localized in the endothelium of segments of the circumventricular vascular bed communicating with the enzymatically equally positive processes of the tanycytes of the third brain ventricle. The findings are briefly discussed from the aspect of the pathogenesis of experimental parkinsonism.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson Secundaria
/
Endotelio Vascular
/
1-Metil-4-fenil-1,2,3,6-Tetrahidropiridina
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Ventrículos Cerebrales
Límite:
Animals
Idioma:
En
Revista:
Folia Morphol (Praha)
Año:
1990
Tipo del documento:
Article
Pais de publicación:
República Checa