Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders.

Morgan, E E; Woods, S P; Letendre, S L; Franklin, D R; Bloss, C; Goate, A; Heaton, R K; Collier, A C; Marra, C M; Gelman, B B; McArthur, J C; Morgello, S; Simpson, D M; McCutchan, J A; Ellis, R J; Abramson, I; Gamst, A; Fennema-Notestine, C; Smith, D M; Grant, I; Vaida, F; Clifford, D B

Morgan, E E; Woods, S P; Letendre, S L; Franklin, D R; Bloss, C; Goate, A; Heaton, R K; Collier, A C; Marra, C M; Gelman, B B; McArthur, J C; Morgello, S; Simpson, D M; McCutchan, J A; Ellis, R J; Abramson, I; Gamst, A; Fennema-Notestine, C; Smith, D M; Grant, I; Vaida, F; Clifford, D B.

Afiliación

Morgan EE; University of California, San Diego, San Diego, CA, USA. eemorgan@ucsd.edu

J Neurovirol ; 19(2): 150-6, 2013 Apr.

Article en En | MEDLINE | ID: mdl-23408335

RESUMEN

This is a cross-sectional, observational study to evaluate the hypothesis that HIV-seropositive (HIV+) apolipoprotein E4 (APOE4) carriers are at increased risk for HIV-associated neurocognitive disorders (HAND) compared to APOE4 noncarriers with HIV in the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) Group sample. APOE genotype was determined in 466 CHARTER participants with varying disease stages and histories of antiretroviral treatment who did not have severe psychiatric or medical comorbid conditions that preclude diagnosis of HAND. HAND diagnoses were based on results of comprehensive neurobehavioral evaluation and use of current neuroAIDS diagnostic criteria. HAND status consists of two levels: neuropsychologically normal status (i.e., no HAND) and any HAND diagnosis (i.e., asymptomatic neurocognitive impairment, minor neurocognitive disorder, HIV-associated dementia). Logistic regression analyses revealed no association between APOE4 carrier status and HAND, and there were no interactions between APOE4 carrier status and ethnicity, age, substance use disorders, duration of infection, or nadir CD4. Results did not differ when analysis was restricted to symptomatic HAND, and no APOE4 gene dose-dependent relationship to HAND emerged. APOE4 status was not associated with concurrent HAND in this large, well-characterized sample. This does not preclude emergence of an association between APOE4 status and HAND as this population ages. Prospective, longitudinal studies are needed to examine APOE4 as a risk factor for neurocognitive decline, incident HAND at older ages, and potential associations with cerebrospinal fluid amyloid.

Asunto(s)

Complejo SIDA Demencia/genética; Complejo SIDA Demencia/fisiopatología; Apolipoproteína E4/genética; Genotipo; Complejo SIDA Demencia/sangre; Complejo SIDA Demencia/tratamiento farmacológico; Adulto; Factores de Edad; Antirretrovirales/uso terapéutico; Terapia Antirretroviral Altamente Activa; Apolipoproteína E4/sangre; Enfermedades Asintomáticas; Recuento de Linfocito CD4; Estudios Transversales; Femenino; Dosificación de Gen; Humanos; Modelos Logísticos; Masculino; Persona de Mediana Edad; Pruebas Neuropsicológicas; Factores de Riesgo; Índice de Severidad de la Enfermedad

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complejo SIDA Demencia / Apolipoproteína E4 / Genotipo Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurovirol Asunto de la revista: NEUROLOGIA / VIROLOGIA Año: 2013 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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