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Effect of tocopherol on biochemical blood parameters in pleuritis-induced rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Calkosinski, Ireneusz; Rosinczuk-Tonderys, Joanna; Bronowicka-Szydelko, Agnieszka; Dzierzba, Katarzyna; Bazan, Justyna; Dobrzynski, Maciej; Majda, Jacek; Gamian, Andrzej.
Afiliación
  • Calkosinski I; Department of Nervous System Diseases, The Faculty of Health Science, Wroclaw Medical University, Poland i.calkosinski@wp.pl.
  • Rosinczuk-Tonderys J; Department of Nervous System Diseases, The Faculty of Health Science, Wroclaw Medical University, Poland.
  • Bronowicka-Szydelko A; Department of Medical Biochemistry, Wroclaw Medical University, Poland.
  • Dzierzba K; Department of Medical Biochemistry, Wroclaw Medical University, Poland.
  • Bazan J; Department of Medical Biochemistry, Wroclaw Medical University, Poland Department of Medical Biochemistry, Wroclaw Medical University, Poland.
  • Dobrzynski M; Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University, Poland.
  • Majda J; Department of Diagnostics Laboratory, 4th Military Academic Hospital in Wroclaw, Poland.
  • Gamian A; Department of Nervous System Diseases, The Faculty of Health Science, Wroclaw Medical University, Poland Polish Academy of Sciences, Institute of Immunology and Experimental Therapy, Wroclaw, Poland.
Toxicol Ind Health ; 31(6): 510-22, 2015 Jun.
Article en En | MEDLINE | ID: mdl-23406955
The aim of this study was to evaluate the effect of tocopherol on pleuritis-induced rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Rats were treated with a single TCDD dose of 5 µg/kg body weight (b.w.) and then for 3 weeks they were daily supplemented with tocopherol at a dose of 30 mg/kg b.w. The inflammation was initiated by intrapleural injection of a single dose of 1% carrageenin solution in a volume of 0.15 ml. Changes in biochemical blood parameters were measured three times at the 24th, 72nd and 120th hour of pleuritis and the blood was collected from 20 animals of each group of rats (group with the control inflammation; group treated with TCDD and with control inflammation; group treated with TCDD, supplemented with tocopherol and with the inflammation). The following biochemical parameters were measured: tumor necrosis factor (TNF), interleukin-1 (IL-1), IL-2, IL-4, IL-6, procollagen, telopeptide, fibrinogen, cholesterol, urea, creatinine, aspartate aminotransferase (AspAT) and alanine aminotransferase (AlAT). Daily supplementation of tocopherol caused significant changes in the level of TNF, IL-1, IL-4, IL-6, urea, creatinine, AspAT and AlAT. According to the results of these studies, we suggest that tocopherol supplementation in high doses could act as a protective treatment to improve liver metabolism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mediadores de Inflamación / Tocoferoles / Inflamación Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Toxicol Ind Health Asunto de la revista: MEDICINA OCUPACIONAL / TOXICOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mediadores de Inflamación / Tocoferoles / Inflamación Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Toxicol Ind Health Asunto de la revista: MEDICINA OCUPACIONAL / TOXICOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido