Differential involvement of central and peripheral α2 adrenoreceptors in the antinociception induced by aerobic and resistance exercise.
Anesth Analg
; 116(3): 703-11, 2013 Mar.
Article
en En
| MEDLINE
| ID: mdl-23400995
BACKGROUND: Several studies have demonstrated antinociception induced by exercise; however, the specific mechanisms for this effect are not well understood. Thus, we investigated the involvement of α2-adrenergic receptors (α2-ARs) in the antinociceptive effect produced by exercise in rats and mice. METHODS: Male Wistar rats performed acute aerobic (AA) and acute resistance exercise protocols, and male α2A/α2C-ARs knockout mice and their wild-type mice were also submitted to AA. RESULTS: After the exercise protocols, the nociceptive threshold of rats and wild type was increased, (except in knockout mice). This effect was reversed by yohimbine, a nonselective α2-ARs antagonist (4 mg/kg, subcutaneously [s.c.]); rauwolscine, a selective α2C-ARs antagonist (4 mg/kg, s.c.); BRL 44408, a selective α2A-ARs antagonist (4 mg/kg, s.c.) and guanethidine, a selective inhibitor of transmission in adrenergic nerves (30 mg/kg, intraperitoneal). Furthermore, when given intrathecally or intracerebroventricularly, yohimbine did not alter antinociception induced by exercise protocols. In addition, α2-ARs expression in rat brains did not change after AA and acute resistance exercise. CONCLUSION: These results suggest a peripheral involvement of α2-ARs in the antinociception induced by aerobic and resistance exercise.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Condicionamiento Físico Animal
/
Dimensión del Dolor
/
Receptores Adrenérgicos alfa 2
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Entrenamiento de Fuerza
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Antagonistas de Receptores Adrenérgicos alfa 2
Límite:
Animals
Idioma:
En
Revista:
Anesth Analg
Año:
2013
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Estados Unidos