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CD34(+) lineage specific donor cell chimerism for the diagnosis and treatment of impending relapse of AML or myelodysplastic syndrome after allo-SCT.
Rosenow, F; Berkemeier, A; Krug, U; Müller-Tidow, C; Gerss, J; Silling, G; Groth, C; Wieacker, P; Bogdanova, N; Mesters, R; Büchner, T; Kienast, J; Berdel, W E; Stelljes, M.
Afiliación
  • Rosenow F; Department of Medicine A/Hematology and Oncology, University of Muenster, Muenster, Germany.
Bone Marrow Transplant ; 48(8): 1070-6, 2013 Aug.
Article en En | MEDLINE | ID: mdl-23376821
After allo-SCT, analysis of CD34(+) lineage-specific donor cell chimerism (DCC) is a sensitive method for monitoring minimal residual disease in patients with AML or myelodysplastic syndrome (MDS) with CD34 expression. To substantiate evidence of whether immune interventions in patients with impending relapse, defined by incomplete lineage-specific DCC, may prevent hematological relapse, we performed a retrospective nested case control study. Unsorted and lineage-specific DCC were measured in 134 patients. Forty-three patients had an incomplete CD34(+)-DCC with no other evidence of relapse. After immediate tapering of immunosuppressive treatment (30 patients) and/or infusion of donor lymphocytes (10 patients), 21 patients remained in remission (conversion to complete lineage-specific DCC) and 22 relapsed. Relapse-free survival at 3 years of the 91 patients with stable DCC and of the 43 patients with incomplete DCC was 74% (95% confidence interval (CI), 64-83%) and 40% (95% CI, 24-58%), respectively. OS rates were 79% (95% CI, 70-88%) and 52% (95% CI, 35-69%), respectively. These results, with 49% of patients with impending relapse successfully treated with immune intervention, highly suggest that analysis of CD34(+)-DCC is an important tool for monitoring and the management of AML and MDS patients after allo-SCT.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes Mielodisplásicos / Células Madre Hematopoyéticas / Leucemia Mieloide Aguda / Trasplante de Células Madre Hematopoyéticas / Antígenos CD34 Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2013 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes Mielodisplásicos / Células Madre Hematopoyéticas / Leucemia Mieloide Aguda / Trasplante de Células Madre Hematopoyéticas / Antígenos CD34 Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2013 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido