HLA-B7 and HLA-DR2 antigens and acute posterior multifocal placoid pigment epitheliopathy.
Arch Ophthalmol
; 108(5): 698-700, 1990 May.
Article
en En
| MEDLINE
| ID: mdl-2334328
Acute posterior multifocal placoid pigment epitheliopathy is a chorioretinal inflammatory disease occurring in young, healthy adults. Its cause is unknown, although it frequently follows a flulike illness. We reexamined 30 patients with documented acute posterior multifocal placoid pigment epitheliopathy to determine their HLA class I antigen (A and B) and class II antigen (DR and DQ) distribution. The HLA class I antigen B7 was found in 12 patients (40.0%) compared with 63 controls (16.6%) (relative risk, 3.38). The class II antigen DR2 was present in 17 patients (56.7%) compared with 107 controls (28.2%) (relative risk, 3.34). The specific role of HLA antigens in uveitis is unknown, but the finding of an increased prevalence of HLA-B7 and HLA-DR2 antigens in patients with acute posterior multifocal placoid pigment epitheliopathy suggests an immunogenetic predisposition to acquiring this disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígeno HLA-B7
/
Antígeno HLA-DR2
/
Coriorretinitis
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Arch Ophthalmol
Año:
1990
Tipo del documento:
Article
Pais de publicación:
Estados Unidos