Oxidative damage to macromolecules in human Parkinson disease and the rotenone model.
Free Radic Biol Med
; 62: 111-120, 2013 Sep.
Article
en En
| MEDLINE
| ID: mdl-23328732
Parkinson disease (PD), the most common neurodegenerative movement disorder, is associated with selective degeneration of nigrostriatal dopamine neurons. Although the underlying mechanisms contributing to neurodegeneration in PD seem to be multifactorial, mitochondrial impairment and oxidative stress are widely considered to be central to many forms of the disease. Whether oxidative stress is a cause or a consequence of dopaminergic death, there is substantial evidence for oxidative stress both in human PD patients and in animal models of PD, especially using rotenone, a complex I inhibitor. There are many indices of oxidative stress, but this review covers the recent evidence for oxidative damage to nucleic acids, lipids, and proteins in both the brain and the peripheral tissues in human PD and in the rotenone model. Limitations of the existing literature and future perspectives are discussed. Understanding how each particular macromolecule is damaged by oxidative stress and the interplay of secondary damage to other biomolecules may help us design better targets for the treatment of PD.
Palabras clave
4-hydroxy-2-nonenal; ATP; CSF; DA; ETC; Free radicals; HNE; L-DOPA; LB; Lewy body; MDA; Macromolecules; O(2)(−); OH(â¢); Oxidative damage; PD; PUFA; Parkinson disease; ROS; Rotenone; SN; VTA; adenosine-5'-triphosphate; cerebrospinal fluid; dopamine; electron transport chain; hydroxyl radical; levodopa, l-3,4-dihydroxyphenylalanine; malondialdehyde; mitochondrial DNA; mtDNA; polyunsaturated fatty acid; reactive oxygen species; substantia nigra pars compacta; superoxide; ventral tegmental area
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Enfermedad de Parkinson Secundaria
/
Estrés Oxidativo
/
Neuronas Dopaminérgicas
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Free Radic Biol Med
Asunto de la revista:
BIOQUIMICA
/
MEDICINA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos