Histologic and cytologic effects of vaginal estrogen in women with pelvic organ prolapse: a randomized controlled trial.
Female Pelvic Med Reconstr Surg
; 19(1): 34-9, 2013.
Article
en En
| MEDLINE
| ID: mdl-23321657
OBJECTIVE: This study aimed to evaluate the histologic and cytologic effects of preoperative vaginal estrogen in women with atrophic vaginitis and pelvic organ prolapse. METHODS: Forty-two women with atrophic vaginitis and stage greater than or equal to 2 prolapse were enrolled in this assessor-blinded randomized controlled trial comparing daily vaginal estrogen cream use for 2 to 12 weeks preoperatively versus no intervention. Data were analyzed using t test and analysis of variance. RESULTS: Of these 42 women, 22 received treatment and 20 were controls. After a mean 7 (3) weeks of use, the vaginal maturity index increased 15.5% in the treatment group and declined 1.5% in the control group (P < 0.001). The vaginal epithelial thickness was 339 (96) µm in the treatment group compared to 302 (119) µm (P = 0.275) in the controls. CONCLUSIONS: Preoperative vaginal estrogen application for 2 to 12 weeks restores vaginal cytology to premenopausal levels, but does not increase vaginal epithelial thickness in women with prolapse.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cuidados Preoperatorios
/
Estrógenos Conjugados (USP)
/
Estrógenos
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Prolapso de Órgano Pélvico
Tipo de estudio:
Clinical_trials
Límite:
Aged
/
Female
/
Humans
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Middle aged
Idioma:
En
Revista:
Female Pelvic Med Reconstr Surg
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos