Analysis of liver viscosity behavior as a function of multifrequency magnetic resonance elastography (MMRE) postprocessing.
J Magn Reson Imaging
; 38(2): 422-8, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23293060
PURPOSE: To analyze the relevance of the viscosity measurement as a liver diagnostic marker. MATERIALS AND METHODS: To determine the level of fibrosis, a Fibroscan test was performed on 40 subjects (10 healthy volunteers and 30 patients). Subsequently, multifrequency magnetic resonance elastography (MMRE) tests were made with a pneumatic driver at 60, 70, and 80 Hz. Phase images were analyzed with two different postprocessing methods, without (Method 1) and with (Method 2) the inversion algorithm (IA), using rheological models (Voigt, springpot) in order to characterize the viscoelastic properties (viscosity: η and elasticity: µ). RESULTS: MRE cartography of the viscous tendency (Gâ³MRE_M2 ) measured within the region of interest (ROI) of the liver increased as a function of the level of fibrosis. Similar results were also obtained for the viscosity (ηmodels_M1 ) calculated with a postprocessing without IA. However, the viscosity (ηmodels_M2 ) remained constant with the stage of fibrosis when the postprocessing was composed of an IA. The experimental (µMRE_M1 and G'MRE_M2 ) and rheological (µmodels_M2 and µmodels_M1 ) elasticities always increased with the level of fibrosis regardless of the postprocessing method. CONCLUSION: The variation of the liver viscosity parameter as a function of postprocessing revealed that this parameter should be further investigated to demonstrate its relevance in clinical practice.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Algoritmos
/
Interpretación de Imagen Asistida por Computador
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Diagnóstico por Imagen de Elasticidad
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Hígado
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Cirrosis Hepática
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Modelos Biológicos
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Magn Reson Imaging
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2013
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Estados Unidos