Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations.
Biol Lett
; 9(1): 20121049, 2013 Feb 23.
Article
en En
| MEDLINE
| ID: mdl-23269844
Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the two transmission pathways to virus growth during multiple rounds of replication remains poorly defined. Here, we fit a mathematical model to previously published and newly generated in vitro data, and determine that free-virus and synaptic transmission contribute approximately equally to the growth of the virus population.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Replicación Viral
/
Infecciones por VIH
/
VIH-1
Límite:
Humans
Idioma:
En
Revista:
Biol Lett
Asunto de la revista:
BIOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido