Association of pre-miR-146a rs2910164 polymorphism with the risk of head and neck cancer.
Anticancer Res
; 33(1): 341-6, 2013 Jan.
Article
en En
| MEDLINE
| ID: mdl-23267167
BACKGROUND: Over- or underexpression of miR-146a has been reported in several different human tumor types, and a polymorphism in its precursor form (pre-miR-146a rs2910164 G/C) has been recently studied in connection with cancer susceptibility. The aim of the present study was to investigate the possible influence of the pre-miR-146a rs2910164 polymorphism on the risk of squamous cell carcinoma of the head and neck (HNSCC). PATIENTS AND METHODS: The study included 468 patients with HNSCC and 468 cancer-free, age-, gender-, and smoking-matched controls. The miR-146a genotypes were determined using polymerase chain reaction with confronting two-pair primers, and their distribution was compared by multivariate binary logistic regression analysis. RESULTS: Occurrence of heterozygous (odds ratio, OR=1.46, 95% confidence interval, CI=1.10-1.95, p=0.009) and C/C homozygous (OR=2.37, 95% CI=1.01-5.60, p=0.048) individuals was significantly more frequent among patients with HNSCC than in the control group. CONCLUSION: The pre-miR/146a C allele may contribute to an increased susceptibility to HNSCC.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Precursores del ARN
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Carcinoma de Células Escamosas
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MicroARNs
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Neoplasias de Cabeza y Cuello
Tipo de estudio:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Anticancer Res
Año:
2013
Tipo del documento:
Article
Pais de publicación:
Grecia