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Effects of two commonly found strains of influenza A virus on developing dopaminergic neurons, in relation to the pathophysiology of schizophrenia.
Landreau, Fernando; Galeano, Pablo; Caltana, Laura R; Masciotra, Luis; Chertcoff, Agustín; Pontoriero, A; Baumeister, Elsa; Amoroso, Marcela; Brusco, Herminia A; Tous, Mónica I; Savy, Vilma L; Lores Arnaiz, María del Rosario; de Erausquin, Gabriel A.
Afiliación
  • Landreau F; Cultivo de Tejidos, Departamento Virología, Instituto Nacional de Enfermedades Infecciosas, ANLIS Dr Carlos G Malbran, Buenos Aires, Argentina.
PLoS One ; 7(12): e51068, 2012.
Article en En | MEDLINE | ID: mdl-23251423
Influenza virus (InfV) infection during pregnancy is a known risk factor for neurodevelopment abnormalities in the offspring, including the risk of schizophrenia, and has been shown to result in an abnormal behavioral phenotype in mice. However, previous reports have concentrated on neuroadapted influenza strains, whereas increased schizophrenia risk is associated with common respiratory InfV. In addition, no specific mechanism has been proposed for the actions of maternal infection on the developing brain that could account for schizophrenia risk. We identified two common isolates from the community with antigenic configurations H3N2 and H1N1 and compared their effects on developing brain with a mouse modified-strain A/WSN/33 specifically on the developing of dopaminergic neurons. We found that H1N1 InfV have high affinity for dopaminergic neurons in vitro, leading to nuclear factor kappa B activation and apoptosis. Furthermore, prenatal infection of mothers with the same strains results in loss of dopaminergic neurons in the offspring, and in an abnormal behavioral phenotype. We propose that the well-known contribution of InfV to risk of schizophrenia during development may involve a similar specific mechanism and discuss evidence from the literature in relation to this hypothesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Esquizofrenia / Encéfalo / Infecciones por Orthomyxoviridae / Subtipo H1N1 del Virus de la Influenza A / Subtipo H3N2 del Virus de la Influenza A / Neuronas Dopaminérgicas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Pregnancy Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2012 Tipo del documento: Article País de afiliación: Argentina Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Esquizofrenia / Encéfalo / Infecciones por Orthomyxoviridae / Subtipo H1N1 del Virus de la Influenza A / Subtipo H3N2 del Virus de la Influenza A / Neuronas Dopaminérgicas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Pregnancy Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2012 Tipo del documento: Article País de afiliación: Argentina Pais de publicación: Estados Unidos