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Long-term effectiveness of radiofrequency ablation for solitary small hepatocellular carcinoma: a retrospective analysis of 363 patients.
Francica, Giampiero; Saviano, Antonio; De Sio, Ilario; De Matthaeis, Nicoletta; Brunello, Franco; Cantamessa, Alessandro; Giorgio, Antonio; Scognamiglio, Umberto; Fornari, Fabio; Giangregorio, Francesco; Piscaglia, Fabio; Gualandi, Silvia; Caturelli, Eugenio; Roselli, Paola; Rapaccini, Gian Ludovico; Pompili, Maurizio.
Afiliación
  • Francica G; Diagnostic and Interventional Unit, S. Maria della Pietà Camilliani Hospital, Via San Rocco 9, 80026 Casoria, Italy. giampierofrancica@gmail.com
Dig Liver Dis ; 45(4): 336-41, 2013 Apr.
Article en En | MEDLINE | ID: mdl-23245589
BACKGROUND: Radiofrequency Ablation is the most widely performed percutaneous treatment for Hepatocellular Carcinoma. This multicentre study was aimed at assessing the complication, overall survival and disease-free survival rates in cirrhotic patients with single Hepatocellular Carcinoma nodule ≤3 cm undergoing Radiofrequency Ablation. METHODS: Data of 365 patients (59% males; mean age 67 ± 8 years), Child-Pugh A/B, with single Hepatocellular Carcinoma nodule ≤3 cm (tumours >2-3 cm = 127/236), showing complete necrosis after Radiofrequency Ablation between 1998 and 2010 in 7 Italian Centers were retrospectively reviewed. Complication, overall survival and disease-free survival rates were analyzed as main clinical end-points. RESULTS: Major complications were observed in 8 patients (2.2%) and minor complications in 23 patients (6.3%). The 3-, and 5-year overall survival rates were 80% and 64%. One hundred and seven patients (29.5%) died, being 41 deaths (38.3%) Hepatocellular Carcinoma-related. At multivariate analysis only age (p = 0.04; OR 2.29), ascites (p < 0.001; OR 3.74) and Child-Pugh class ≥B8 (p = 0.003; OR 2.42) were confirmed as independent predictors for overall survival. The disease-free survival rates at 3- and 5-year were 50%, and 41.8%. CONCLUSIONS: Radiofrequency Ablation is an effective and safe tool for the treatment of single Hepatocellular Carcinoma ≤3 cm providing excellent 5-year overall survival and disease-free survival rates. Patient's age and liver status appeared as main determinants of outcome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ablación por Catéter / Carcinoma Hepatocelular / Neoplasias Hepáticas / Recurrencia Local de Neoplasia Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Dig Liver Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2013 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ablación por Catéter / Carcinoma Hepatocelular / Neoplasias Hepáticas / Recurrencia Local de Neoplasia Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Dig Liver Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2013 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos