Rapid NK-cell activation in chicken after infection with infectious bronchitis virus M41.
Vet Immunol Immunopathol
; 151(3-4): 337-41, 2013 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-23245429
Natural killer (NK) cells are cytotoxic lymphocytes and play an important role in the early defence against viruses. In this study we focussed on NK cell and interferon (IFN) responses after infection with infectious bronchitis virus (IBV). Based on surface expression of CD107+, enhanced activation of lung NK cells was observed at 1 dpi, whereas in blood prolonged NK-cell activation was found. IFN-α and IFN-ß mRNA and proteins were not rapidly induced whereas IFN-γ production in lung, measured by Elispot assay, increased over time at 2 and 4 dpi. In contrast, IFN-γ production in blood was highest at 1 dpi and decreased over time down to levels comparable to uninfected birds at 4 dpi. Collectively, infection with IBV-M41 resulted in activation of NK cells in the lung and blood and rapid production of IFN-γ and not IFN-α and IFN-ß compared to uninfected birds.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades de las Aves de Corral
/
Células Asesinas Naturales
/
Pollos
/
Infecciones por Coronavirus
/
Virus de la Bronquitis Infecciosa
Límite:
Animals
Idioma:
En
Revista:
Vet Immunol Immunopathol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Países Bajos