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Expression of Ki67 and CD105 as proliferation and angiogenesis markers in salivary gland tumors.
Tadbir, Azadeh Andisheh; Pardis, Soheil; Ashkavandi, Zohreh Jafari; Najvani, Ali Dehghani; Ashraf, Mohammad Javad; Taheri, Ali; Zadeh, Maryam Asad; Sardari, Yasaman.
Afiliación
  • Tadbir AA; Depatment of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. Azadehandishehtadbir@yahoo.com
Asian Pac J Cancer Prev ; 13(10): 5155-9, 2012.
Article en En | MEDLINE | ID: mdl-23244127
OBJECTIVE: To investigate the association between CD105 and tumor cell proliferation in salivary gland tumors. METHODS: In this study, 59 samples of salivary tumors from Khalili Hospital archive, including 20 cases of pleomorphic adenoma (PA), 20 cases of mucoepidermoid carcinoma (MEC) and 19 cases of adenoid cystic carcinoma, as well as 10 cases of normal salivary gland tissue, were reviewed by immunohistochemistry (IHC) for CD105 and Ki67 staining. RESULTS: CD105 positive vessels were absent in normal salivary gland tissue in the vicinity of tumors (51.6% of all tumors were positive). There was a statistically significant difference in frequency of CD105 staining between PA and malignant tumors and between four groups of different lesions (p<0.000) being highest in MEC. Intratumoral microvessel density was also elevated in malignant neoplasms (2.61 ± 3.1) as compared to PA (0.46 ± 0.6). Normal salivary glands did not express Ki67. There was a statistically significant difference in frequency and percentage of Ki67 immunoreactivity in malignant neoplasms (86.5% and 10.7 ± 10.8 respectively) compared to PA (50% and 0.78 ± 0.2) and among the four groups values were highest in MEC (p<0.000). CONCLUSION: n this study, it was observed a higher rate of angiogenesis and cellular proliferation was noted in malignant tumors compared to benign tumors, but no correlation was observed between these two markers.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándulas Salivales / Neoplasias de las Glándulas Salivales / Antígenos CD / Receptores de Superficie Celular / Antígeno Ki-67 / Proliferación Celular / Neovascularización Patológica Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Asian Pac J Cancer Prev Asunto de la revista: NEOPLASIAS Año: 2012 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Tailandia
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándulas Salivales / Neoplasias de las Glándulas Salivales / Antígenos CD / Receptores de Superficie Celular / Antígeno Ki-67 / Proliferación Celular / Neovascularización Patológica Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Asian Pac J Cancer Prev Asunto de la revista: NEOPLASIAS Año: 2012 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Tailandia