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Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region.
Niibori, Yosuke; Yu, Tzong-Shiue; Epp, Jonathan R; Akers, Katherine G; Josselyn, Sheena A; Frankland, Paul W.
Afiliación
  • Niibori Y; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.
Nat Commun ; 3: 1253, 2012.
Article en En | MEDLINE | ID: mdl-23212382
Different places may share common features, but are coded by distinct populations of CA3 neurons in the hippocampus. Here we show that chemical or genetic suppression of adult neurogenesis in the hippocampus impairs this population-based coding of similar (but not dissimilar) contexts. These data provide a neural basis for impaired spatial discrimination following ablation of adult neurogenesis, and support the proposal that adult neurogenesis regulates the efficiency of a pattern separation process in the hippocampus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neurogénesis / Región CA3 Hipocampal Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2012 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neurogénesis / Región CA3 Hipocampal Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2012 Tipo del documento: Article Pais de publicación: Reino Unido