Characterizing the memory of the GAL regulatory network in Saccharomyces cerevisiae.
Syst Synth Biol
; 5(3-4): 97-104, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-23205153
Genetic regulatory networks respond dynamically to perturbations in the intracellular and extracellular environments of an organism. The GAL system in the yeast Saccharomyces cerevisiae has evolved to utilize galactose as an alternative carbon and energy source, in the absence of glucose in the environment. We present a dynamic model for GAL system in Saccharomyces cerevisiae, which includes a novel mechanism for Gal3p activation upon induction with galactose. The modification enables the model to simulate the experimental observation that in absence of galactose, oversynthesis of Gal3p can also induce the GAL system. We then characterize the memory of the GAL system as the domain of attraction of the steady states.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Syst Synth Biol
Año:
2011
Tipo del documento:
Article
Pais de publicación:
Alemania