Protease-resistant peptide design-empowering nature's fragile warriors against HIV.
Biopolymers
; 98(5): 431-42, 2012.
Article
en En
| MEDLINE
| ID: mdl-23203688
Peptides have great potential as therapeutic agents, but their use is often limited by susceptibility to proteolysis and their resulting in vivo fragility. In this review, we focus on peptidomimetic approaches to produce protease-resistant peptides with the potential for greatly improved clinical utility. We focus on the use of mirror-image (D-peptide) and ß-peptides as two leading approaches with distinct design principles and challenges. Application to the important and difficult problem of inhibiting HIV entry illustrates the current state-of-the-art in peptidomimetic technologies. We also summarize future directions for this field and highlight remaining obstacles to widespread use of protease-resistant peptides.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptido Hidrolasas
/
Péptidos
/
Diseño de Fármacos
/
Infecciones por VIH
/
Inhibidores de la Proteasa del VIH
Límite:
Humans
Idioma:
En
Revista:
Biopolymers
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos