Concise review: stem cell therapy for muscular dystrophies.
Stem Cells Transl Med
; 1(11): 833-42, 2012 Nov.
Article
en En
| MEDLINE
| ID: mdl-23197695
Muscular dystrophy comprises a group of genetic diseases that cause progressive weakness and degeneration of skeletal muscle resulting from defective proteins critical to muscle structure and function. This leads to premature exhaustion of the muscle stem cell pool that maintains muscle integrity during normal use and exercise. Stem cell therapy holds promise as a treatment for muscular dystrophy by providing cells that can both deliver functional muscle proteins and replenish the stem cell pool. Here, we review the current state of research on myogenic stem cells and identify the important challenges that must be addressed as stem cell therapy is brought to the clinic.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Satélite del Músculo Esquelético
/
Células Madre Pluripotentes
/
Trasplante de Células Madre
/
Distrofias Musculares
Límite:
Humans
Idioma:
En
Revista:
Stem Cells Transl Med
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido