Relationship between atypical T- and B-cell size predicts survival in peripheral T-cell lymphomas with large B-cells.

Tan, Leonard Hwan Cheong; Tan, Soo Yong; Tang, Tiffany; Lim, Soon Thye; Tan, Daryl; Lim, Lay Cheng; Kam, Grace Li Shan; Linn, Yeh Ching; Loh, Tze Ping; Tao, Miriam; Koay, Evelyn Siew Chuan

Tan, Leonard Hwan Cheong; Tan, Soo Yong; Tang, Tiffany; Lim, Soon Thye; Tan, Daryl; Lim, Lay Cheng; Kam, Grace Li Shan; Linn, Yeh Ching; Loh, Tze Ping; Tao, Miriam; Koay, Evelyn Siew Chuan.

Afiliación

Tan LH; Department of Pathology, Singapore General Hospital, Singapore. leonard.tan.h.c@sgh.com.sg

Pathology ; 45(1): 28-37, 2013 01.

Article en En | MEDLINE | ID: mdl-23196903

RESUMEN

BACKGROUND: Pathological prognostication for peripheral T-cell lymphomas (PTCLs) complicated by large B-cell (LBC) proliferations has not been previously devised. METHODS: Forty-six cases of PTCL with LBCs were reviewed immunohistologically, by in situ hybridisation for Epstein-Barr virus encoded RNA and polymerase chain reaction analyses for T-cell receptor (TCR) clonality. Follow-up intervals ranged from 1 to 149 months (mean 40 months). RESULTS: Cases with atypical T-cell size equal to or exceeding that of interspersed LBCs (ATEB+, nâ=â12, including an ALK negative anaplastic large cell lymphoma) had significantly inferior disease-specific survival compared to ATEB negative (ATEB-, nâ=â34) cases (pâ=â0.002 for all cases and pâ=â0.014 when restricted to TCR clonal cases, nâ=â30) [hazard ratio 11.2; 95% confidence interval (CI) 0.94-85.0, pâ=â0.019]. All recorded deaths amongst ATEB+ cases occurred in 26 months, while TCR polyclonal ATEB- cases (nâ=â9) had none; TCR clonal ATEB- cases (nâ=â22) had 62% 5-year survival (95% CI 33-91%, pâ=â0.001). There was no survival separation between angioimmunoblastic (nâ=â25) and unspecified (nâ=â20) subsets of PTCL (pâ=â0.957). CONCLUSION: In PTCLs, cytological grading using harboured LBCs as internal yardsticks, as well as molecular genotypic measures of lymphoma cell burden, have prognostic value.

Asunto(s)

Linfocitos B/patología; Herpesvirus Humano 4/aislamiento & purificación; Linfoma de Células T Periférico/patología; Linfocitos T/patología; Adulto; Anciano; Anciano de 80 o más Años; Antígenos CD/inmunología; Linfocitos B/inmunología; Linfocitos B/metabolismo; Proliferación Celular; Tamaño de la Célula; Células Clonales; Estudios de Cohortes; Quimioterapia Combinada; Femenino; Estudios de Seguimiento; Reordenamiento Génico de Linfocito T; Herpesvirus Humano 4/inmunología; Humanos; Inmunofenotipificación; Linfoma de Células T Periférico/tratamiento farmacológico; Linfoma de Células T Periférico/genética; Linfoma de Células T Periférico/mortalidad; Masculino; Persona de Mediana Edad; Clasificación del Tumor; Pronóstico; Receptores de Antígenos de Linfocitos T/genética; Receptores de Antígenos de Linfocitos T/inmunología; Linfocitos T/inmunología; Linfocitos T/metabolismo; Resultado del Tratamiento

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos B / Linfocitos T / Linfoma de Células T Periférico / Herpesvirus Humano 4 Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Pathology Año: 2013 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido

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