Lupus erythematosus: a short account.

Feller, L; Motswaledi, M H; Chandran, R; Chikte, U M E; Meyerov, R; Lemmer, J

Feller, L; Motswaledi, M H; Chandran, R; Chikte, U M E; Meyerov, R; Lemmer, J.

Afiliación

Feller L; Department of Periodontology and Oral Medicine, School of Oral Health Sciences, Faculty of Health Sciences, University of Limpopo, Medunsa Campus, South Africa. Ifeller@ul.ac.za

SADJ ; 66(5): 234-6, 2011 Jun.

Article en En | MEDLINE | ID: mdl-23193865

RESUMEN

Lupus erythematosus is a chronic autoimmune inflammatory disease with diverse clinical manifestations including arthritis, skin disorders and kidney disease. Pathologically it is characterised by complex interactions between multiple genetic, epigenetic and extraneous factors; and serologically by the presence of a variety of antibodies which are reactive to intracellular molecular constituents. Impaired clearance of apoptotic cells and of immune complexes, loss of immune tolerance to self-antigens and dysregulation of the cytokine network act synergistically with extraneous factors such as ultraviolet radiation, viruses and certain drugs to induce and sustain lupus erythematosus.

Asunto(s)

Lupus Eritematoso Sistémico/inmunología; Enfermedades Autoinmunes/inmunología; Autoinmunidad/inmunología; Predisposición Genética a la Enfermedad/genética; Humanos; Tolerancia Inmunológica; Lupus Eritematoso Sistémico/genética; Polimorfismo Genético/genética

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lupus Eritematoso Sistémico Límite: Humans Idioma: En Revista: SADJ Asunto de la revista: ODONTOLOGIA Año: 2011 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Sudáfrica

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