Cytotoxic bioactivity of some phenylpropanoic acid derivatives.
Nat Prod Commun
; 7(10): 1341-6, 2012 Oct.
Article
en En
| MEDLINE
| ID: mdl-23157005
In this study, we synthesized a series of phenylpropanoic acid derivatives based on modifications at four selected points of the molecular scaffold. The in vitro antiproliferative activities of the compounds were examined in representative human solid tumor cell lines. A SAR was established pointing out the relevance of the substituents. The best activity profiles were obtained for the derivatives bearing more lipophilic esters (GI50 3.1-21 microM).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenilpropionatos
/
Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
Nat Prod Commun
Asunto de la revista:
BOTANICA
/
FARMACOLOGIA
/
QUIMICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Argentina
Pais de publicación:
Estados Unidos