Relevance of serum copper elevation induced by oral contraceptives: a meta-analysis.
Contraception
; 87(6): 790-800, 2013 Jun.
Article
en En
| MEDLINE
| ID: mdl-23153894
BACKGROUND AND STUDY DESIGN: It is well documented that copper (Cu) blood levels are elevated in combination oral contraceptive (COC) users. The aim of this study was to establish the range of Cu increase in OC users compared to nonusers through a systematic literature overview and quantitative data analysis. RESULTS: Twenty-six articles were included in the meta-analysis. The increase in Cu level exponentially decreased in COC users over time, with a rapid decline through the 1960s and 1970s. After controlling for the publication year, use of COC increases the mean serum/plasma Cu level by 0.57 mg/L (95% confidence interval 0.49-0.66 mg/L). CONCLUSION: COCs commonly raise serum Cu to levels between 1.5 and 2 mg/L, which are above reference levels. Although these levels are not considered toxic, there are suggestions that such Cu increase could be implicated in oxidative pathophysiological processes in the body. Further research on safety of COCs use, including oxidative-stress-related effects, is warranted.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Regulación hacia Arriba
/
Anticonceptivos Orales
/
Cobre
Tipo de estudio:
Systematic_reviews
Límite:
Female
/
Humans
Idioma:
En
Revista:
Contraception
Año:
2013
Tipo del documento:
Article
País de afiliación:
Croacia
Pais de publicación:
Estados Unidos