Shape string: a new feature for prediction of DNA-binding residues.
Biochimie
; 95(2): 354-8, 2013 Feb.
Article
en En
| MEDLINE
| ID: mdl-23116714
Protein-DNA interactions are involved in many biological processes essential for gene expression and regulation. To understand the molecular mechanisms of protein-DNA recognition, it is crucial to analyze and identify DNA-binding residues of protein-DNA complexes. Here, we proposed a novel descriptor shape string and another two related features shape string PSSM and shape string pair composition to characterize DNA-binding residues. We employed the new features and the position-specific scoring matrix (PSSM) for modeling and prediction. The results of a benchmark dataset showed that our approach significantly improved the accuracy of the predictor. The overall accuracy of our approach reached 85.86% with 85.02% sensitivity and 86.02% specificity. The results also demonstrated that shape string is a powerful descriptor for the prediction of DNA-binding residues. The additional two related features enhanced the predictive value.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Algoritmos
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Programas Informáticos
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ADN
/
Proteínas
/
Posición Específica de Matrices de Puntuación
Tipo de estudio:
Diagnostic_studies
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Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Biochimie
Año:
2013
Tipo del documento:
Article
Pais de publicación:
Francia