Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications.

Gabbiani, Chiara; Scaletti, Federica; Massai, Lara; Michelucci, Elena; Cinellu, Maria A; Messori, Luigi

Gabbiani, Chiara; Scaletti, Federica; Massai, Lara; Michelucci, Elena; Cinellu, Maria A; Messori, Luigi.

Afiliación

Gabbiani C; Department of Chemistry and Industrial Chemistry, Pisa, Italy.

Chem Commun (Camb) ; 48(95): 11623-5, 2012 Dec 11.

Article en En | MEDLINE | ID: mdl-23100062

RESUMEN

Based on ESI-MS measurements, we show here that some representative cytotoxic gold(III) compounds produce stable adducts upon reaction with the copper chaperone Atox-1; notably, such adducts contain gold in the oxidation state +1. These findings are of interest to understand the intracellular metabolism of medicinal gold species and to develop new potent inhibitors of the copper trafficking system.

Asunto(s)

Cobre/metabolismo; Oro/química; Metalochaperonas/química; Complejos de Coordinación/química; Proteínas Transportadoras de Cobre; Humanos; Metalochaperonas/metabolismo; Chaperonas Moleculares; Oxidación-Reducción

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cobre / Metalochaperonas / Oro Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2012 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido

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