Synthesis of some novel 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime ester derivatives and evaluation of their anticonvulsant activity.
Eur J Med Chem
; 57: 275-82, 2012 Nov.
Article
en En
| MEDLINE
| ID: mdl-23085104
Twenty-three new oxime ester derivatives of nafimidone were synthesized with the prospect of potential anticonvulsant activities. MES and ScM tests were employed for their anticonvulsant activities and rotorod test for neurological deficits. Eighteen compounds were found to be protective against MES seizures. Alkyl (1-8) and arylalkyl (9, 10) oxime ester derivatives were found to be more active than aryl oxime ester derivatives (11-23). Five compounds (2, 3, 7, 9, 10), which were protective at 0.5 h at the doses of 30 mg/kg and higher in MES test, showed the highest activity. Compound 17 was the most active one in ScM test at all dose levels at 4 h.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oximas
/
Convulsiones
/
Imidazoles
/
Anticonvulsivantes
/
Nafazolina
Límite:
Animals
Idioma:
En
Revista:
Eur J Med Chem
Año:
2012
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Francia