Size-selective detection in integrated optical interferometric biosensors.
Opt Express
; 20(19): 20934-50, 2012 Sep 10.
Article
en En
| MEDLINE
| ID: mdl-23037217
We present a new size-selective detection method for integrated optical interferometric biosensors that can strongly enhance their performance. We demonstrate that by launching multiple wavelengths into a Young interferometer waveguide sensor it is feasible to derive refractive index changes from different regions above the waveguide surface, enabling one to distinguish between bound particles (e.g. proteins, viruses, bacteria) based on their differences in size and simultaneously eliminating interference from bulk refractive index changes. Therefore it is anticipated that this new method will be ideally suited for the detection of viruses in complex media. Numerical calculations are used to optimize sensor design and the detection method. Furthermore the specific case of virus detection is analyzed theoretically showing a minimum detectable virus mass coverage of 4 × 10(2) fg/mm(2) < (typically corresponding to 5 × 10(1) particles/ml).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Técnicas Biosensibles
/
Fenómenos Ópticos
/
Interferometría
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Opt Express
Asunto de la revista:
OFTALMOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Estados Unidos