Bioactive oligostilbenoids from Shorea maxwelliana King and their chemotaxonomic significance.

Zawawi, N K N A; Ahmat, N; Mazatulikhma, M Z; Shafiq, R M; Wahid, N H; Sufian, A S

Zawawi, N K N A; Ahmat, N; Mazatulikhma, M Z; Shafiq, R M; Wahid, N H; Sufian, A S.

Afiliación

Zawawi NK; Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), 40450, Shah Alam, Malaysia.

Nat Prod Res ; 27(17): 1589-93, 2013.

Article en En | MEDLINE | ID: mdl-23035830

RESUMEN

Phytochemical investigation on the stem bark of Shorea maxwelliana yielded five oligostilbenoids identified as α-viniferin (1), maximol A (2), vaticanol A (3), suffruticosol A (4) and vaticanol G (5). Chemotaxonomy of isolated compounds was discussed briefly. Major compounds were tested for neurotoxic and cytotoxic activities. Neurotoxicity for all tested compounds did not pose any toxic effect against cultured cell (cell viability range ±100-94%). Compounds 2-5 possessed active cyctotoxic activity against HL60 cell line with IC50 values range of 2.7-78 µg mL(-1).

Asunto(s)

Dipterocarpaceae/química; Corteza de la Planta/química; Estilbenos/química; Benzofuranos/química; Benzofuranos/farmacología; Supervivencia Celular/efectos de los fármacos; Células HL-60; Humanos; Extractos Vegetales/química; Extractos Vegetales/farmacología; Estilbenos/farmacología

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estilbenos / Corteza de la Planta / Dipterocarpaceae Límite: Humans Idioma: En Revista: Nat Prod Res Año: 2013 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Reino Unido

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