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Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population.
Gardener, S; Gu, Y; Rainey-Smith, S R; Keogh, J B; Clifton, P M; Mathieson, S L; Taddei, K; Mondal, A; Ward, V K; Scarmeas, N; Barnes, M; Ellis, K A; Head, R; Masters, C L; Ames, D; Macaulay, S L; Rowe, C C; Szoeke, C; Martins, R N.
Afiliación
  • Gardener S; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Transl Psychiatry ; 2: e164, 2012 Oct 02.
Article en En | MEDLINE | ID: mdl-23032941
The Mediterranean diet (MeDi), due to its correlation with a low morbidity and mortality for many chronic diseases, has been widely recognised as a healthy eating model. We aimed to investigate, in a cross-sectional study, the association between adherence to a MeDi and risk for Alzheimer's disease (AD) and mild cognitive impairment (MCI) in a large, elderly, Australian cohort. Subjects in the Australian Imaging, Biomarkers and Lifestyle Study of Ageing cohort (723 healthy controls (HC), 98 MCI and 149 AD participants) completed the Cancer Council of Victoria Food Frequency Questionnaire. Adherence to the MeDi (0- to 9-point scale with higher scores indicating higher adherence) was the main predictor of AD and MCI status in multinominal logistic regression models that were adjusted for cohort age, sex, country of birth, education, apolipoprotein E genotype, total caloric intake, current smoking status, body mass index, history of diabetes, hypertension, angina, heart attack and stroke. There was a significant difference in adherence to the MeDi between HC and AD subjects (P < 0.001), and in adherence between HC and MCI subjects (P < 0.05). MeDi is associated with change in Mini-Mental State Examination score over an 18-month time period (P < 0.05) in HCs. We conclude that in this Australian cohort, AD and MCI participants had a lower adherence to the MeDi than HC participants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cooperación del Paciente / Dieta Mediterránea / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male País/Región como asunto: Oceania Idioma: En Revista: Transl Psychiatry Año: 2012 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cooperación del Paciente / Dieta Mediterránea / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male País/Región como asunto: Oceania Idioma: En Revista: Transl Psychiatry Año: 2012 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos