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Immunoglobulin kappa C predicts overall survival in node-negative breast cancer.
Chen, Zonglin; Gerhold-Ay, Aslihan; Gebhard, Susanne; Boehm, Daniel; Solbach, Christine; Lebrecht, Antje; Battista, Marco; Sicking, Isabel; Cotarelo, Christina; Cadenas, Cristina; Marchan, Rosemarie; Stewart, Joanna D; Gehrmann, Mathias; Koelbl, Heinz; Hengstler, Jan G; Schmidt, Marcus.
Afiliación
  • Chen Z; Department of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany.
PLoS One ; 7(9): e44741, 2012.
Article en En | MEDLINE | ID: mdl-23028600
BACKGROUND: Biomarkers of the immune system are currently not used as prognostic factors in breast cancer. We analyzed the association of the B cell/plasma cell marker immunoglobulin kappa C (IGKC) and survival of untreated node-negative breast cancer patients. MATERIAL AND METHODS: IGKC expression was evaluated by immunostaining in a cohort of 335 node-negative breast cancer patients with a median follow-up of 152 months. The prognostic significance of IGKC for disease-free survival (DFS) and breast cancer-specific overall survival (OS) was evaluated with Kaplan-Meier survival analysis as well as univariate and multivariate Cox analysis adjusted for age at diagnosis, pT stage, histological grade, estrogen receptor (ER) status, progesterone receptor (PR) status, Ki-67 and human epidermal growth factor receptor 2 (HER-2) status. RESULTS: 160 patients (47.7%) showed strong expression of IGKC. Univariate analysis showed that IGKC was significantly associated with DFS (P = 0.017, hazard ratio [HR] = 0.570, 95% confidence interval [CI] = 0.360-0.903) and OS (P = 0.011, HR = 0.438, 95% CI = 0.233-0.822) in the entire cohort. The significance of IGKC was especially strong in ER negative and in luminal B carcinomas. In multivariate analysis IGKC retained its significance independent of established clinical factors for DFS (P = 0.004, HR = 0.504, 95% CI = 0.315-0.804) as well as for OS (P = 0.002, HR = 0.371, 95% CI = 0.196-0.705). CONCLUSION: Expression of IGKC has an independent protective impact on DFS and OS in node-negative breast cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Cadenas kappa de Inmunoglobulina Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2012 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Cadenas kappa de Inmunoglobulina Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2012 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos