[Analysis of the polymorphism of the genome region of HIV-1 encoding the fusion protein].
Vopr Virusol
; 57(4): 9-13, 2012.
Article
en Ru
| MEDLINE
| ID: mdl-23012977
The prevalence of the mutations associated with HIV fusion inhibitor enfuvirtide resistance in Russia and CIS countries was studied. Enfuvirtide resistance mutations were not observed among studied viruses in Russia and CIS countries so far. It was found that high rate (35%) of natural polymorphism mutations were associated with enfuvirtide hypersusceptibility. It was also found that high frequency of accessory mutations N126K and E137K were observed in the HR2 region (27.5%). The accessory mutations in HR2 can contribute to increased resistance and improve viral fitness. Our data were compared with those obtained in similar previous studies.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteína gp41 de Envoltorio del VIH
/
Infecciones por VIH
/
VIH-1
/
Mutación
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
Ru
Revista:
Vopr Virusol
Año:
2012
Tipo del documento:
Article
Pais de publicación:
Rusia