Minimal change disease in graft versus host disease: a podocyte response to the graft?
Clin Nephrol
; 80(6): 469-73, 2013 Dec.
Article
en En
| MEDLINE
| ID: mdl-23006339
Nephrotic syndrome is a rare complication of hematopoietic cell transplantation. It has been suggested that nephrotic syndrome may represent a limited form of graft-versus-host disease although the pathological link between these two entities remains unclear. In this paper, we report a case of a 61-year-old female who underwent nonmyeloablative allogenic stem cell transplantation for T-cell prolymphocytic leukemia and subsequently developed biopsy proven minimal change disease shortly after cessation of her immunosuppression therapy. Urinary CD80 was markedly elevated during active disease and disappeared following corticosteroid-induced remission. We hypothesize that alloreactive donor T cells target the kidney and induce podocyte expression of CD80 that results in proteinuria from limited 'graft versus host' disease.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trasplante de Células Madre Hematopoyéticas
/
Podocitos
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Enfermedad Injerto contra Huésped
/
Nefrosis Lipoidea
Tipo de estudio:
Etiology_studies
Límite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Clin Nephrol
Año:
2013
Tipo del documento:
Article
Pais de publicación:
Alemania