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Coexistence of macro- and micro-vascular abnormalities in newly diagnosed normal tension glaucoma patients.
Mroczkowska, Stephanie; Ekart, Aniko; Sung, Velota; Negi, Anil; Qin, Lu; Patel, Sunni R; Jacob, Sarita; Atkins, Carole; Benavente-Perez, Alexandra; Gherghel, Doina.
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  • Mroczkowska S; Vascular Research Laboratory, Ophthalmic Research Group, School of Life and Health Sciences, Aston University, Birmingham, UK.
Acta Ophthalmol ; 90(7): e553-9, 2012 Nov.
Article en En | MEDLINE | ID: mdl-22998650
PURPOSE: To investigate the coexistence of ocular microvascular and systemic macrovascular abnormalities in early stage, newly diagnosed and previously untreated normal tension glaucoma patients (NTG). METHODS: Retinal vascular reactivity to flickering light was assessed in 19 NTG and 28 age-matched controls by means of dynamic retinal vessel analysis (IMEDOS GmbH, Jena, Germany). Using a newly developed computational model, the entire dynamic vascular response profile to flicker light was imaged and used for analysis. In addition, assessments of carotid intima-media thickness (IMT) and pulse wave analysis (PWA) were conducted on all participants, along with blood pressure (BP) measurements and blood analyses for lipid metabolism markers. RESULTS: Patients with NTG demonstrated an increased right and left carotid IMT (p = 0.015, p = 0.045) and an elevated PWA augmentation index (p = 0.017) in comparison with healthy controls, along with an enhanced retinal arterial constriction response (p = 0.028), a steeper retinal arterial constriction slope (p = 0.031) and a reduced retinal venous dilation response (p = 0.026) following flicker light stimulation. CONCLUSIONS: Early stage, newly diagnosed, NTG patients showed signs of subclinical vascular abnormalities at both macro- and micro-vascular levels, highlighting the need to consider multi-level circulation-related pathologies in the development and progression of this type of glaucoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Retina / Vasos Retinianos / Glaucoma de Baja Tensión Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Acta Ophthalmol Asunto de la revista: OFTALMOLOGIA Año: 2012 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Retina / Vasos Retinianos / Glaucoma de Baja Tensión Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Acta Ophthalmol Asunto de la revista: OFTALMOLOGIA Año: 2012 Tipo del documento: Article Pais de publicación: Reino Unido