[The role of the type-three secretion system of the gram-negative bacteria in regulation of chronic infections].
Mol Gen Mikrobiol Virusol
; (3): 3-13, 2012.
Article
en Ru
| MEDLINE
| ID: mdl-22984766
The role of the type-three secretion system of the gram-negative bacteria in regulation of chronic infections is discussed. Recent research showed that most of severe chronic somatic diseases are derived from chronic infection induced in the first place by infectious agents. The role of the T3SS of different species in transition from an acute infection to persistence is reviewed. Clinical and bacteriological research showed that microorganisms are persistent in the form resistant to antibiotics. That is why one of the promising targets for the development of antibacterial new-generation treatment is T3SS that conducts transport of bacteria pathogenicity factors into eukaryotic cell. The presence of this structure is necessary for the development of an acute infectious process and chronization of an infection is essential for its functioning.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Salmonella
/
Infecciones Bacterianas
/
Yersinia
/
Chlamydia
/
Sistemas de Secreción Bacterianos
Límite:
Humans
Idioma:
Ru
Revista:
Mol Gen Mikrobiol Virusol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MICROBIOLOGIA
/
VIROLOGIA
Año:
2012
Tipo del documento:
Article
Pais de publicación:
Rusia