Role of dopaminergic receptors in the human dura mater in the pathogenesis of headache.
Clin Ter
; 163(3): e101-6, 2012.
Article
en En
| MEDLINE
| ID: mdl-22964699
AIMS: We hypothesize that dopaminergic receptors of dura mater may play a possible role in headache. MATERIALS AND METHODS: The dopaminergic receptors of cranial dura mater in man were studied by examining several dural zones (vascular, peri-vascular, inter-vascular) in different brain regions (basal, calvarial, tentorial, occipital, frontal, parietal, temporal). RESULTS: Our results demonstrate that dopaminergic receptors are present in human cranial dura mater and that these receptors show a specific morphological location. There are more dural dopaminergic receptors in the basal region than in the calvarial one. Moreover, these receptors are more abundant in the vascular and perivascular dural zone than in the intervascular one. CONCLUSIONS: The location of dopaminergic receptors in the dura mater may represent an important factor in the pathogenesis of headache. Further studies will be necessary in order to determine the role of dopaminergic system in this disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores Dopaminérgicos
/
Duramadre
/
Cefalea
Tipo de estudio:
Etiology_studies
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Clin Ter
Año:
2012
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Italia