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Heme- and nonheme-iron absorption and iron status 12 mo after sleeve gastrectomy and Roux-en-Y gastric bypass in morbidly obese women.
Ruz, Manuel; Carrasco, Fernando; Rojas, Pamela; Codoceo, Juana; Inostroza, Jorge; Basfi-Fer, Karen; Valencia, Alejandra; Csendes, Attila; Papapietro, Karin; Pizarro, Fernando; Olivares, Manuel; Westcott, Jamie L; Hambidge, K Michael; Krebs, Nancy F.
Afiliación
  • Ruz M; Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile. mruz@med.uchile.cl
Am J Clin Nutr ; 96(4): 810-7, 2012 Oct.
Article en En | MEDLINE | ID: mdl-22952172
BACKGROUND: The effect of bariatric surgery on iron absorption is only partially known. OBJECTIVE: The objective was to study the effects of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGBP) on heme- and nonheme-iron absorption and iron status. DESIGN: Fifty-eight menstruating women were enrolled in this prospective study [mean (±SD) age: 35.9 ± 9.1 y; weight: 101.7 ± 13.5 kg; BMI (in kg/m²): 39.9 ± 4.4]. Anthropometric, body-composition, dietary, and hematologic indexes and heme- and nonheme-iron absorption-using a standardized meal containing 3 mg Fe-were determined before and 12 mo after surgery. Forty-three subjects completed the 12-mo follow-up. Iron supplements were strictly controlled. RESULTS: Heme-iron absorption was 23.9% before and 6.2% 12 mo after surgery (P < 0.0001). Nonheme-iron absorption decreased from 11.1% to 4.7% (P < 0.0001). No differences were observed by type of surgery. Iron intakes from all sources of supplements were 27.9 ± 6.2 mg/d in the SG group and 63.2 ± 21.1 mg/d in the RYGBP group (P < 0.001). Serum ferritin and total-body iron decreased more after RYGBP than after SG. CONCLUSIONS: Iron (heme and nonheme) absorption is markedly reduced after SG and RYGBP. The magnitude of the decrease in heme-iron absorption is greater than that of nonheme iron. The amounts suggested as iron supplements may need to be increased to effectively prevent iron-status impairment.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Derivación Gástrica / Estado Nutricional / Hierro de la Dieta / Gastrectomía / Hemo / Absorción Intestinal Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans País/Región como asunto: America do sul / Chile Idioma: En Revista: Am J Clin Nutr Año: 2012 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Estados Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Derivación Gástrica / Estado Nutricional / Hierro de la Dieta / Gastrectomía / Hemo / Absorción Intestinal Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans País/Región como asunto: America do sul / Chile Idioma: En Revista: Am J Clin Nutr Año: 2012 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Estados Unidos