Balancing the dose in the mouse.
Results Probl Cell Differ
; 55: 231-45, 2012.
Article
en En
| MEDLINE
| ID: mdl-22918810
Organisms that use a chromosomal basis of sex determination have a problem of gene inequality. In the mouse, this dimorphism is evident by the presence of two X-chromosomes in females, while males have a single X- and a single Y-chromosome. To balance this disparity, one of the two female X-chromosomes is transcriptionally silenced to neutralize the gene dose with the XY male. Dosage compensation in mammals is known as X-chromosome inactivation (XCI) and is a crucial early developmental process. XCI is an example of epigenetics: a phenotype resulting in changes on a chromosome without a change in nucleic acid sequence. Studies in mouse embryology and genetics have answered many questions about the process of balancing the dose. In this chapter, I highlight how the mouse dosage compensates the gene disparity between XX females and XY males in a crucial epigenetic process called X-chromosome inactivation (XCI).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cromosoma X
/
Cromosoma Y
/
Dosificación de Gen
/
Procesos de Determinación del Sexo
/
Silenciador del Gen
/
Desarrollo Embrionario
/
Inactivación del Cromosoma X
Límite:
Animals
Idioma:
En
Revista:
Results Probl Cell Differ
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Alemania