[Modulation of epithelial differentiation of cultured rat bladder carcinoma]. / Modulation de la différenciation épithéliale d'un carcinome vésical de rat en culture.
Pathol Biol (Paris)
; 38(10): 982-7, 1990 Dec.
Article
en Fr
| MEDLINE
| ID: mdl-2290698
Epithelium-to-mesenchyme transformation plays a key role in tissue remodelling in embryos since it allows cells from the primitive epithelia to migrate to other sites where they participate in the formation of new structures. A similar phenomenon may be involved in the detachment of malignant cells from neighboring primary tumor cells, which is a prerequisite to the invasion of neighboring tissues or the development of metastases. To test this hypothesis, an in vitro model using a rat bladder carcinoma cell line was developed. Cells exhibited epithelial features under standard culture conditions. After exposure to a soluble inducer (acidic FGF) or the specific extracellular matrix components (collagens), the cells acquired a fibroblastic phenotype, separated from one another, and started to move freely on the substrate. Inducers were found to act synergistically on the fibroblastic transformation of carcinoma cells and to promote the penetration of these cells into collagen gels.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Vejiga Urinaria
/
Carcinoma
/
Transformación Celular Neoplásica
Límite:
Animals
Idioma:
Fr
Revista:
Pathol Biol (Paris)
Año:
1990
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Francia