Design of a novel gut bacterial adhesion model for probiotic applications.
Artif Cells Nanomed Biotechnol
; 41(2): 116-24, 2013 Apr.
Article
en En
| MEDLINE
| ID: mdl-22889228
A new gut bacterial adhesion model has been developed. For this, a continuous-flow bioreactor packed with bacteria-coated beads was designed to simulate the gut lining and other features. In vitro model efficacy shows successful bacterial cell gut adhesions: bacterial adhesion was higher with mucin-alginate compared to controls. In feasibility study, adhesion of Lactobacillus fermentum NCIMB 5221 and Lactobacillus reuteri NCIMB 701359 was investigated for their metabolic activities for bile salt. Bile salt hydrolase (BSH)-active Lactobacillus reuteri exerted higher activity than non-BSH-active L. fermentum. This model has potential use in gut health, probiotic, bacterial cell gut adhesion and other delivery applications.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Ácidos y Sales Biliares
/
Probióticos
/
Limosilactobacillus fermentum
/
Limosilactobacillus reuteri
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Amidohidrolasas
/
Modelos Anatómicos
Límite:
Humans
Idioma:
En
Revista:
Artif Cells Nanomed Biotechnol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Reino Unido