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Identification of 4,5-dihydro-4-hydroxygeldanamycins as shunt products of geldanamycin biosynthesis.
Li, Ting; Ni, Siyang; Jia, Changhong; Wang, Hongyuan; Sun, Guizhi; Wu, Linzhuan; Gan, Maoluo; Shan, Guangzhi; He, Weiqing; Lin, Ling; Zhou, Hongxia; Wang, Yiguang.
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  • Li T; Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China.
J Nat Prod ; 75(8): 1480-4, 2012 Aug 24.
Article en En | MEDLINE | ID: mdl-22849774
Two new geldanamycin (GDM) analogues, (4S)-4,5-dihydro-4-hydroxygeldanamycin (1) and (4R)-4,5-dihydro-4-hydroxygeldanamycin (2), were identified from Streptomyces hygroscopicus 17997. Compounds 1 and 2 were not normal intermediates of GDM biosynthesis but shunt products of C-4,5 oxidation catalyzed by GdmP, a cytochrome P450 oxidase acting as a desaturase in GDM biosynthesis. Preliminary assays implied that, compared with GDM, 1 and 2 exhibited decreased cytotoxicity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptomyces / Benzoquinonas / NADPH-Ferrihemoproteína Reductasa / Lactamas Macrocíclicas Tipo de estudio: Diagnostic_studies Idioma: En Revista: J Nat Prod Año: 2012 Tipo del documento: Article Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptomyces / Benzoquinonas / NADPH-Ferrihemoproteína Reductasa / Lactamas Macrocíclicas Tipo de estudio: Diagnostic_studies Idioma: En Revista: J Nat Prod Año: 2012 Tipo del documento: Article Pais de publicación: Estados Unidos