Brain isozyme of glycogen phosphorylase: immunohistological localization within the central nervous system.

Ignacio, P C; Baldwin, B A; Vijayan, V K; Tait, R C; Gorin, F A

Ignacio, P C; Baldwin, B A; Vijayan, V K; Tait, R C; Gorin, F A.

Afiliación

Ignacio PC; Department of Neurology, University of California, Davis 95616.

Brain Res ; 529(1-2): 42-9, 1990 Oct 08.

Article en En | MEDLINE | ID: mdl-2282504

RESUMEN

An antibody specific for the predicted carboxyterminal sequence of the human brain isozyme of glycogen phosphorylase (alpha-1,4-D-glucan:orthophosphate D-glucosyltransferase, EC 2.4.1.1) was generated to verify the carboxyterminal amino acid sequence of this protein. The isozyme-specific antibody was used to examine the localization of this protein in primate and non-primate brain. The highest levels of the brain isozyme in cerebrum and cerebellum were found in fibrous astrocytes, many with glial processes that appear to terminate upon blood vessels.

Asunto(s)

Encéfalo/enzimología; Isoenzimas/análisis; Fosforilasas/análisis; Animales; Astrocitos/enzimología; Cerebelo/enzimología; Corteza Cerebral/enzimología; Ensayo de Inmunoadsorción Enzimática; Humanos; Immunoblotting; Técnicas para Inmunoenzimas; Isoenzimas/inmunología; Macaca; Fibras Nerviosas Mielínicas; Fosforilasas/inmunología; Ratas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Fosforilasas / Isoenzimas Límite: Animals / Humans Idioma: En Revista: Brain Res Año: 1990 Tipo del documento: Article Pais de publicación: Países Bajos

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