Antioxidant properties of ß-seleno amines against lipid peroxidation in rat brain and liver.
Environ Toxicol Pharmacol
; 34(2): 446-453, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-22797322
ß-Seleno amines were screened for in vitro antioxidant activity. The compounds (C1-C4) were tested against lipid peroxidation induced by iron and sodium nitroprusside in rat brain and liver homogenates. The compounds showed inhibition against thiobarbituric acid reactive species (TBARS) induced by different pro-oxidants (10µM FeSO(4) and 5µM sodium nitroprusside (SNP) in rat brain and liver homogenates. The compounds exhibited strong antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and phosphomolybdenum assays. The IC(50) values revealed that the ß-seleno amines in which the amino group was protected with protecting groups tert-butyloxycarbonyl (Boc) and Tosyl (Ts) groups showed better antioxidant profiles compared to the free monoselenides. The total antioxidant activity of C1, C2, C3 and C4 were found to be 85.2±11.5, 114±7.9, 138±8.5, 125.81±5.2µM/ml of ascorbic acid respectively. Therefore, these compounds may be used as synthetic antioxidants.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Peroxidación de Lípido
/
Compuestos de Organoselenio
/
Aminas
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Antioxidantes
Límite:
Animals
Idioma:
En
Revista:
Environ Toxicol Pharmacol
Año:
2012
Tipo del documento:
Article
Pais de publicación:
Países Bajos