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Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4).
Duell, E J; Lucenteforte, E; Olson, S H; Bracci, P M; Li, D; Risch, H A; Silverman, D T; Ji, B T; Gallinger, S; Holly, E A; Fontham, E H; Maisonneuve, P; Bueno-de-Mesquita, H B; Ghadirian, P; Kurtz, R C; Ludwig, E; Yu, H; Lowenfels, A B; Seminara, D; Petersen, G M; La Vecchia, C; Boffetta, P.
Afiliación
  • Duell EJ; Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain. Electronic address: eduell@iconcologia.net.
  • Lucenteforte E; Department of Epidemiology, Institute for Pharmacological Research 'Mario Negri', Milan; Department of Preclinical and Clinical Pharmacology 'Mario Aiazzi Mancini', University of Florence, Florence, Italy.
  • Olson SH; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York.
  • Bracci PM; Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco.
  • Li D; Department of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston.
  • Risch HA; Department of Epidemiology and Public Health, School of Public Health, School of Medicine, Yale University, New Haven.
  • Silverman DT; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA.
  • Ji BT; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA.
  • Gallinger S; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
  • Holly EA; Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco.
  • Fontham EH; School of Public Health, Louisiana State University, New Orleans, USA.
  • Maisonneuve P; Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.
  • Bueno-de-Mesquita HB; National Institute for Public Health and the Environment, Bilthoven; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands.
  • Ghadirian P; Epidemiology Research Unit, Research Centre of the University of Montreal Hospital Centre (CRCHUM), Montreal, Canada.
  • Kurtz RC; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York.
  • Ludwig E; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York.
  • Yu H; Department of Epidemiology and Public Health, School of Public Health, School of Medicine, Yale University, New Haven; Cancer Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu.
  • Lowenfels AB; Department of Surgery, New York Medical College, Valhalla.
  • Seminara D; Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda.
  • Petersen GM; Departments of Health Science Research, Gastroenterology, and Medical Genetics, Mayo Clinic College of Medicine, Rochester, USA.
  • La Vecchia C; Department of Epidemiology, Institute for Pharmacological Research 'Mario Negri', Milan; Department of Occupational Health, University of Milan, Milan, Italy.
  • Boffetta P; The Tisch Cancer Institute and Institute for Translational Epidemiology, Mt Sinai School of Medicine, New York, USA.
Ann Oncol ; 23(11): 2964-2970, 2012 Nov.
Article en En | MEDLINE | ID: mdl-22767586
BACKGROUND: Pancreatitis is a known risk factor for pancreatic cancer; however, an unknown fraction of the disease is thought to be a consequence of tumor-related duct obstruction. PATIENTS AND METHODS: A pooled analysis of a history of pancreatitis and risk of pancreatic cancer was carried out considering the time interval between diagnoses and potential modification by covariates. Adjusted pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from 10 case-control studies (5048 cases of ductal pancreatic adenocarcinoma and 10,947 controls) taking part in the International Pancreatic Cancer Case-Control Consortium (PanC4). RESULTS: The association between pancreatitis and pancreatic cancer was nearly three-fold at intervals of >2 years between diagnoses (OR: 2.71, 95% CI: 1.96-3.74) and much stronger at intervals of ≤2 years (OR: 13.56, 95% CI: 8.72-21.90) probably reflecting a combination of reverse causation and antecedent misdiagnosis of pancreas cancer as pancreatitis. The younger (<65 years) pancreatic cancer cases showed stronger associations with previous (>2 years) pancreatitis (OR: 3.91, 95% CI: 2.53-6.04) than the older (≥65 years) cases (OR: 1.68, 95% CI: 1.02-2.76; P value for interaction: 0.006). CONCLUSIONS: Despite a moderately strong association between pancreatitis (diagnosed before >2 years) and pancreatic cancer, the population attributable fraction was estimated at 1.34% (95% CI: 0.612-2.07%), suggesting that a relatively small proportion of pancreatic cancer might be avoided if pancreatitis could be prevented.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Pancreatitis Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2012 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Pancreatitis Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2012 Tipo del documento: Article Pais de publicación: Reino Unido