[Antagonism of Zn2+ on nootropic action of piracetam in mice].

Zhu, T J; Chen, X Y; Pan, J C; Zhang, S S

Zhu, T J; Chen, X Y; Pan, J C; Zhang, S S.

Afiliación

Zhu TJ; Department of Pharmacology, Wenzhou Medical College, China.

Zhongguo Yao Li Xue Bao ; 11(2): 100-2, 1990 Mar.

Article en Zh | MEDLINE | ID: mdl-2275380

RESUMEN

In mouse step-down test, the memory impairments of acquisition, consolidation and recognition were induced by anisodine, chloramphenical and ethanol, respectively. Piracetam 100 mg/(kg.d) ip for 5 d improved the anisodine-induced impairment of learning. ZnSO4 5 mg/(kg.d) po for 5 d did not improve the 3 impairments. Memory impairments were enhanced by a combined administration of ZnSO4 and piracetam in these 3 models. These results were confirmed by Y-maze method in normal mice.

Asunto(s)

Aprendizaje/efectos de los fármacos; Memoria/efectos de los fármacos; Piracetam/farmacología; Sulfatos/antagonistas & inhibidores; Zinc/antagonistas & inhibidores; Animales; Femenino; Masculino; Ratones; Sulfato de Zinc

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piracetam / Sulfatos / Zinc / Aprendizaje / Memoria Límite: Animals Idioma: Zh Revista: Zhongguo Yao Li Xue Bao Año: 1990 Tipo del documento: Article País de afiliación: China Pais de publicación: China

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