Circulating microRNA is a biomarker of biliary atresia.
J Pediatr Gastroenterol Nutr
; 55(4): 366-9, 2012 Oct.
Article
en En
| MEDLINE
| ID: mdl-22732895
OBJECTIVE: The lack of reliable noninvasive diagnostic biomarkers of biliary atresia (BA) results in delayed diagnosis and worsened patient outcome. Circulating microRNAs (miRNAs) are a new class of noninvasive biomarkers with encouraging diagnostic utility. METHODS: We examined the ability of serum miRNAs to distinguish BA from other forms of neonatal hyperbilirubinemia. BA-specific serum miRNAs were identified using a microfluidic array platform and validated in a larger, independent sample set. RESULTS: The miR-200b/429 cluster was significantly increased in the sera of patients with BA relative to infants with non-BA cholestatic disorders. CONCLUSIONS: Circulating levels of the miR-200b/429 cluster are elevated in infants with BA and have promising diagnostic clinical performance.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Atresia Biliar
/
Colestasis
/
MicroARNs
/
Hiperbilirrubinemia
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
/
Prognostic_studies
Límite:
Animals
/
Humans
/
Infant
Idioma:
En
Revista:
J Pediatr Gastroenterol Nutr
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos